TRANSCEND is a project funded by HORIZON Innovation Actions whose main area of research is the identification of Transformational Adaptation Policies (TAP) to water scarcity. TAP will be implemented in 7 labs: Júcar River Basin (RB) (Spain); Reno RB (Italy); Tympaki RB (Greece); Nitra RB (Slovakia); Caplina-Mauri-Desaguadero RB (Peru, Chile & Bolivia); Orontes RB (Lebanon, Syria & Turkey); and Mahanadi RB (Indian states of Chhattisgarh & Odisha). TRANSCEND will leverage this diverse set of demonstrators to initiate adoption of the ecosystem of innovation in 8+ inspiration labs, train 160+ transformation agents, and mainstream uncertainty analysis in key national and European Green Deal strategies. This will provide the knowledge and tools to catalyze robust and systemic transformations to water scarcity and climate change globally, with a clear impact pathway towards TAP adoption in 100+ basins by 2030.