Recognizing the central role played by snow, ice and permafrost in the global climate system, the LIQUIDICE project joins expert cryospheric observers and modelers to: i) comprehensively re-assess the past and future century-plus of climate-induced high impact changes to the Greenland ice sheet and climate vulnerable locations across the Alps, Norway, High Mountain Asia (HMA) and Svalbard, including permafrost areas and their ecosystems; ii) develop new, expanded and harmonized data from satellite Earth Observation (EO) and ground stations; iii) use these data to improve and test a hierarchy of ice sheet and glacier models with Earth System Models (ESMs); iv) through these steps, yield new process understanding, and ultimately v) inform water resource, hydropower, and socio-economic strategies through clear and transparent communication of results and uncertainties. The project’s strengths lie in new multidisciplinary collaborations across 18 research institutions, from eight European countries (Poland, Italy, Denmark, Germany, Spain, Sweden, Norway, United Kingdom) and India, encompassing expertise in field observations, satellite EO techniques, ESM development and application, and socio-economic analysis. Key deliverables include a) FAIR-principled new multi-decade data catalogues of multi-regional snow water equivalent and a 44-year EO-derived albedo record; b) assessments of impact of model resolution and degree of coupling on results; c) refined past and future glacier, ice cap and Greenland ice sheet freshwater fluxes to oceans and global sea level rise with indirect constraint on Antarctica; d) new hydrological simulations for HMA; e) a new framework for a Water Discharge Impact Assessments; f) socio-economic integrated risk and adaptation assessments;